IPy₂BF₄‐Promoted Intramolecular Addition of Masked and Unmasked Anilines to Alkynes: Direct Assembly of 3‐Iodoindole Cores

Abstract

All at once! Indoles can be assembled and iodinated in a one-pot process (see scheme) from anilines and their derivatives. This metal-free addition of nitrogen compounds to alkynes is a clean reaction that is promoted by iodonium cations. Such a process provides a general pathway towards utilization of the biologically relevant indole core.