Diastereoselective Aldol Reaction of <i>N</i>,<i>N</i>-Dibenzyl-α-amino Aldehydes with Ketones Catalyzed by Proline

Abstract

[reaction: see text] L-proline-catalyzed direct aldol reaction of L-amino acid-derived N,N-dibenzyl amino aldehydes with acetone, cyclopentanone, or hydroxyacetone provides gamma-amino-beta-hydroxy- or gamma-amino-alpha,beta-dihydroxy-ketones with moderate to excellent yields and diastereoselectivities.