<i>rac</i>-1,2-DIACYLOXYPROPYL-3-ARSONIC ACIDS: ARSONOLIPID ANALOGUES OF PHOSPHONOLIPIDS

Abstract

Abstract A new class of lipids, arsonolipids or rac-1,2-diacyloxypropyl-3-arsonic acids, have been synthesized by acylating tetrabutyl ammonium hydrogen rac-1,2-dihydroxypropyl-3-arsonate with myristic, palmitic and stearic anhydrides in the presence of pyridine. The yields are moderate to low due to decomposition of rac-1,2-dihydroxypropyl-3-arsonic acid and its salts by acylating agents. Acid salts of arsonolipids were prepared by neutralization but neutral salts could not be made.