Concepedia

Synthesis of Polysubstituted Imidazo[1,2-<i>a</i>]pyridines via Microwave-Assisted One-Pot Cyclization/Suzuki Coupling/Palladium-Catalyzed Heteroarylation

Jamal Koubachi, Saı̈d El Kazzouli, Sabine Berteina‐Raboin, Abderrahim Mouaddib, Gérald Guillaumet

The Journal of Organic Chemistry · 2007 · 91 citations · 29 references

DOI

Concepts

Abstract

A new and efficient method for the synthesis of 2,3,6-trisubstituted imidazo[1,2-a]pyridine derivatives using a microwave-assisted one-pot, two-step Suzuki/heteroarylation or one-pot, three-step cyclization/Suzuki/heteroarylation was developed. Polysubstituted compounds are obtained in good yield from 2-amino-5-halogenopyridines, 2-halogenocarbonyl derivatives, boronic acids, and heteroaryl bromides.

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