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Preparation of 7-Halo-indoles by Thallation of N-Formylindoline and Their Attempted Use for Synthesis of the Right-Hand Segment of Chloropeptin

Y. Yamada, Shiho Arima, Chiharu Okada, Ai Akiba, Toshitsugu Kai, Yoshihiro Harigaya

Chemical and Pharmaceutical Bulletin · 2006 · 13 citations · 16 references

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Abstract

7-Substituted (Cl, Br, I) indoles were synthesized by using thallation of N-formylindoline as a key reaction. Two precursor tripeptides for the right-hand segment of chloropeptin were synthesized by using (R)-7'-iodo and 7'-bromotryptophans derived from each 7-substituted indole (I, Br) obtained by the above procedure.

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