Sporolides A and B: Structurally Unprecedented Halogenated Macrolides from the Marine Actinomycete <i>Salinispora</i> <i>t</i> <i>ropica</i>

Abstract

[structure: see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.