Synthesis · 1999 · 59 citations · 0 references
Life SciencesMedicinal ChemistryCarbohydrate ChemistryGlycobiologySynthetic Medicinal ChemistryCarbohydrate SynthesisGlycan BiosynthesisN-linked GlycosylationPeptide Bond ChemistryPeptide ChemistryProtein GlycosylationAsparagine-linked GlycosylationGlutamine SynthesisGlycan Building Block SynthesisGlycomimetic SynthesisGlycopeptide SynthesisGlycoside SynthesisGlycosylation Method DevelopmentN-linked Glycan Synthesis
N β-Glycosylated-asparagine and -glutamine derivatives, which are useful precursors for the synthesis of N-glucopeptides and their analogs, were obtained in good yields by the reaction of a glycosyl azide and an N α-protected-aspartic/glutamic acid α-monoester in the presence of trialkylphosphine at low temperature.