Application of the Bifunctional Phosphonylating Agent Bis[6-(trifluoromethyl)benzotriazol-1-yl] Methylphosphonate Towards the Preparation of Isosteric D-<i>myo</i>-Inositol Phospholipid and Phosphate Analogues - Concepedia

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Application of the Bifunctional Phosphonylating Agent Bis[6-(trifluoromethyl)benzotriazol-1-yl] Methylphosphonate Towards the Preparation of Isosteric D-<i>myo</i>-Inositol Phospholipid and Phosphate Analogues

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References

1991

Year

C. E. DREEF, M. Douwes, C. J. J. Elie, G. A. VAN DER MAREL, Jacques H. van Boom

Medicinal ChemistryBiochemistryNatural SciencesMedicineOrganic ChemistryPhosphate AnaloguesSynthetic ChemistryPharmacologySodium MethylphosphonatePhosphatidyl D-myo-inositol ADrug DiscoveryD-myo -Inositol 1-

Abstract

The individual diastereoisomeric methylphosphonate analogues of phosphatidyl D-myo-inositol A (R p and S p) and D-myo -inositol 1-(sodium methylphosphonate) were prepared using the bifunctional phosphonylating agent bis[6-(trifluoromethyl)benzotriazol-1-yl] methylphosphonate.