Synthesis and Reactivity of Some Mannich Bases. VII. Synthesis of 3-(2-Dialkylaminoethyl)-1,2-benzisoxazoles

Abstract

Absrroct -3-(2-Dialkyl-noethyl).1,2-benzisoxaroles(2) are accessible by direct cycliration ofthe corresponding Mannich bases oxime acetates (11) in refluxing benzene in the presence of anhydrous potassium carbonate.The previously known methods for ring closure to 1.2-benzisoxazole wee ineffective forthis class ofpharmacologically relevant compounds.