Concepedia

Attenuation of Palmitic Acid–Induced Lipotoxicity by Chlorogenic Acid through Activation of SIRT1 in Hepatocytes

Lele Yang, Jinchao Wei, Feiya Sheng, Peng Li

Molecular Nutrition & Food Research · 2019 · 45 citations · 31 references

Abstract

Collectively, these findings show that supplementation with CGA protects hepatocytes from FFA-induced lipotoxicity through activation of SIRT1, which reverses the oxidative stress and dysfunction of mitochondrial biogenesis directly.

References

31

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Marie Lagouge, Carmen Argmann, Zachary Gerhart‐Hines et al. · Cell · 2006 · 3.9K citations · Full text

Metabolic Syndrome, Mitochondrial Function, Biochemistry +10

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Anne Brunet, Lora B. Sweeney, James Fitzhugh Sturgill et al. · Science · 2004 · 3.2K citations

Genetics, Cell Death, Gene Regulatory Network +19

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

Nathan L. Price, Ana P. Gomes, Alvin J. Y. Ling et al. · Cell Metabolism · 2012 · 1.5K citations · Full text

Reductive Stress, Biochemistry, Mitochondrial Function +8

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

Zachary Gerhart‐Hines, Joseph T. Rodgers, Olivia Bare et al. · The EMBO Journal · 2007 · 1.3K citations · Full text

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

Aparna Purushotham, Thaddeus T. Schug, Qing Xu et al. · Cell Metabolism · 2009 · 1.1K citations · Full text

Inflammation, Metabolic Syndrome, Metabolic Associated Steatohepatitis +14