Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines via an Intramolecular Aza-Wittig reaction. Synthesis of the antibiotic DC-81

Iminophosphoranes: Useful Building Blocks for the Preparation of Nitrogen-Containing Heterocycles

Pedro Molina, Marı́a Jesús Vilaplana · Synthesis · 1994 · 297 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15

Covalent binding of antitumor antibiotics in the minor groove of DNA. Mechanism of action of CC-1065 and the pyrrolo(1,4)benzodiazepines

Laurence H. Hurley, Donald R. VanDevanter · Accounts of Chemical Research · 1986 · 124 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Pyrrolo[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B

R. Petrusek, Gary L. Anderson, Tim F. Garner et al. · Biochemistry · 1981 · 98 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Total synthesis of anthramycin

W. Leimgruber, Andrew D. Batcho, Rafał Czajkowski · Journal of the American Chemical Society · 1968 · 92 citations

Pharmacy, Medicinal Chemistry, Drug Design +6

A versatile and efficient synthesis of carbinolamine-containing pyrrolo[1,4]benzodiazepines via the cyclization of N-(2-aminobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetals: total synthesis of prothracarcin

David R. Langley, David E. Thurston · The Journal of Organic Chemistry · 1987 · 76 citations

Natural Sciences, Chemistry, Pharmacology +7