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α-EWG-Substituted Enones: Suitable Substrates for Ring-Closing Metathesis
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2006
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α-Ewg-substituted EnonesEngineeringEnantioselective SynthesisAlkene MetathesisRing-closing MetathesisNatural SciencesDiversity-oriented SynthesisOrganic ChemistryChemistryHexacyclinic AcidSynthetic Chemistryα-Ewg-substituted EnoneBiomolecular Engineering
The A-ring of hexacyclinic acid has been synthesised, using a ring-closing metathesis involving an α-EWG-substituted enone as the key step. We have then explored the scope of this reaction, which gives access to various 5- and 6-membered rings.