Uncatalysed Preparation of α-Amino Phosphonates under Solvent Free Conditions

Abstract

A simple, efficient and environmentally friendly procedure has been developed for the three component coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphites to produce α-amino phosphonates. The α-amino phosphonates are synthesised in high yields (74–97%) in a few minutes (1–3 min) by microwave irradiation under solvent-free conditions, avoiding the use of any catalyst.