Concepedia

The SR-B1 Receptor as a Potential Target for Treating Glioblastoma

Ethan Berney, Nirupama Sabnis, Marlyn Panchoo, Sangram Raut, Rob D. Dickerman, Andras G. Lacko

Journal of Oncology · 2019 · 28 citations · 27 references

DOIFull text

Open access

Abstract

These studies present strong proof of concept regarding the efficacy of delivering EVR and likely other agents, via a biocompatible transport system, targeted to the SR-B1 receptor that is upregulated in most cancers, including GBM. Targeting the SR-B1 receptor could thus lead to effective personalized therapy of GBM.

References

27

Targeted Delivery of Small Interfering RNA Using Reconstituted High-Density Lipoprotein Nanoparticles

Mian M.K. Shahzad, Lingegowda S. Mangala, Hee Dong Han et al. · Neoplasia · 2011 · 219 citations · Full text

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High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme

Padma Kadiyala, Dan Li, Fernando M. Núñez et al. · ACS Nano · 2019 · 210 citations

A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K

J. Daniel, Evanthia Galanis, S. Keith Anderson et al. · Neuro-Oncology · 2014 · 162 citations · Full text

Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL‐associated vitamin E

Daniel Goti, Andelko Hrzenjak, Sanja Levak‐Frank et al. · Journal of Neurochemistry · 2001 · 143 citations

Biomimetic, synthetic HDL nanostructures for lymphoma

Shuo Yang, Marina G. Damiano, Heng Zhang et al. · Proceedings of the National Academy of Sciences · 2013 · 127 citations · Full text

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