Urotensin-#receptor antagonist SB-706375 protected isolated rat heart from ischaemia–reperfusion injury by attenuating myocardial necrosis via RhoA/ROCK/RIP3 signalling pathway

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

Ting Zhang, Yan Zhang, Mingyao Cui et al. · Nature Medicine · 2016 · 793 citations

Life Sciences, Biochemistry, Cell Biology +14

Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.

David Pearson, John E. Shively, Brian R. Clark et al. · Proceedings of the National Academy of Sciences · 1980 · 393 citations · Full text

Life Sciences, Biochemistry, Zoology +13

Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury

Weike Bao · Cardiovascular Research · 2004 · 222 citations

Medicine, Cardiology, Pharmacology +14

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873

Kai Wang, Fang Liu, Tao An et al. · Cell Death and Differentiation · 2016 · 215 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium

Shabaz A. Hamid, Hugo S. Bower, Gary F. Baxter · American Journal of Physiology-Heart and Circulatory Physiology · 2007 · 118 citations · Full text

Life Sciences, Cardiology, Cell Biology +13