Synthesis of thiophene derivatives and their anti-microbial, antioxidant, anticorrosion and anticancer activity

Abstract

Antimicrobial screening results showed that compound <b>S</b> _<b>1</b> was the most potent antibacterial agent against <i>Staphylococcus aureus, Bacillus subtilis</i>, <i>Escherichia coli</i> and <i>Salmonella typhi</i> having MIC value 0.81 µM/ml and compound <b>S</b> _<b>4</b> also displayed excellent antifungal activity against both <i>Candida albicans</i> and <i>Aspergillus niger</i> (MIC = 0.91 µM/ml) when compared with cefadroxil (antibacterial) and fluconazole (antifungal) as standard drug. The antioxidant screening results indicated that compound <b>S</b> _<b>4</b> and <b>S</b> _<b>6</b> exhibited excellent antioxidant activity with IC₅₀ values <b>48.45</b> and <b>45.33</b> respectively when compared with the ascorbic acid as standard drug. Anticorrosion screening results indicated that compound <b>S</b> _<b>7</b> showed more anticorrosion efficiency (97.90%) with low corrosion rate. Results of anticancer screening indicated that compound <b>S</b> _<b>8</b> showed effective cytotoxic activity against human lung cancer cell line (A-549) at dose of 10^-4 M when compared with adriamycin as standard.