Highly regio- and enantioselective synthesis of chiral intermediate for pregabalin using one-pot bienzymatic cascade of nitrilase and amidase

Development of a Chemoenzymatic Manufacturing Process for Pregabalin

Carlos A. Martínez, Shanghui Hu, Yves Dumond et al. · Organic Process Research & Development · 2008 · 241 citations

Engineering, Biotechnology, Chemistry +16

A simple method to determine the enantiomeric ratio in enantioselective biocatalysis

J. L. L. Rakels, Adrie J. J. Straathof, Joseph J. Heijnen · Enzyme and Microbial Technology · 1993 · 228 citations

Engineering, Biotechnology, Chemistry +16

An Enantioselective Synthesis of (<i>S</i>)-(+)-3-Aminomethyl-5-methylhexanoic Acid via Asymmetric Hydrogenation

Mark J. Burk, Pieter D. de Koning, Todd M. Grote et al. · The Journal of Organic Chemistry · 2003 · 139 citations

Natural Sciences, Chemistry, Catalysis +12

Nitrile Hydratase Activity of a Recombinant Nitrilase

Bruno C. M. Fernandes, César Mateo, Christoph Kiziak et al. · Advanced Synthesis & Catalysis · 2006 · 105 citations

Life Sciences, Biochemistry, Chemistry +12

The Nitrilase ZmNIT2 Converts Indole-3-Acetonitrile to Indole-3-Acetic Acid

Woong June Park, Verena Kriechbaumer, Axel Müller et al. · PLANT PHYSIOLOGY · 2003 · 94 citations · Full text

Life Sciences, Plant Biology, Plant Sciences +16