Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

E. Sally Ward, Detlef Güssow, Andrew D. Griffiths et al. · Nature · 1989 · 992 citations

Life Sciences, Microbiology, Molecular Biology +14

Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

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Medicine, Neuroscience, Physiology +17

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

Paul Morgan, Piet H. van der Graaf, John Arrowsmith et al. · Drug Discovery Today · 2011 · 677 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.

Richard P. Junghans, Clark L. Anderson · Proceedings of the National Academy of Sciences · 1996 · 676 citations

Life Sciences, Biochemistry, Immunology +14

The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan

Chaity Chaudhury, Samina Mehnaz, John M. Robinson et al. · The Journal of Experimental Medicine · 2003 · 637 citations · Full text

Life Sciences, Biochemistry, Immunology +14