Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Elizabeta Nemeth, Marie S. Tuttle, Julie Powelson et al. · Science · 2004 · 4.8K citations

Medicine, Cell Biology, Physiology +17

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications · 1997 · 4K citations

Life Sciences, Biochemistry, Molecular Biology +14

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

Life Sciences, Biochemistry, Cell Biology +12

Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis

Jasbir Makker, Ahmad Hanif, Bharat Bajantri et al. · Case Reports in Gastroenterology · 2015 · 1.4K citations · Full text

Medicine, Genetics, Hematology +17

Identification of erythroferrone as an erythroid regulator of iron metabolism

Léon Kautz, Grace Jung, Erika V. Valore et al. · Nature Genetics · 2014 · 1.1K citations · Full text

Medicine, Biochemistry, Physiology +12