Concepedia

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships

Leo Leung, Dan Niculescu‐Duvaz, Deborah A. Smithen, Filipa M. Lopes, Cedric Callens, Robert McLeary, Grazia Saturno, Lawrence Davies, Mohammed Aljarah, Michael Brown,

Journal of Medicinal Chemistry · 2019 · 70 citations · 12 references

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Concepts

Abstract

) in a LOX enzyme activity assay. Further SAR optimization yielded the orally bioavailable LOX inhibitor CCT365623 with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy.

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