Methionine enkephalin (MENK) regulates the immune pathogenesis of type 2 diabetes mellitus via the IL-33/ST2 pathway

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler, Juliette Janson, Susan Bonner‐Weir et al. · Diabetes · 2003 · 4K citations

Medicine, Endocrinology, Physiology +17

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

Jochen Schmitz, Alexander M. Owyang, Elizabeth R. Oldham et al. · Immunity · 2005 · 3.7K citations · Full text

Life Sciences, Immunology, Cell Signaling +13

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

Shoji Sanada, Daihiko Hakuno, Luke Higgins et al. · Journal of Clinical Investigation · 2007 · 1K citations · Full text

Life Sciences, Cardiology, Pharmacology +17

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Jonathan R. Brestoff, Brian Kim, Steven A. Saenz et al. · Nature · 2014 · 930 citations

Life Sciences, Immunology, Physiology +17

IL-33 is a crucial amplifier of innate rather than acquired immunity

Keisuke Oboki, Tatsukuni Ohno, Naoki Kajiwara et al. · Proceedings of the National Academy of Sciences · 2010 · 650 citations

Life Sciences, Immunology, Pathology +17