Concepedia

A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix

Howard Seeherman, Stephen P. Berasi, Christopher Brown, Robert Martinez, Z. Sean Juo, Scott A. Jelinsky, Michael Cain, Jaclyn Grode, Kathleen E. Tumelty, Marc Bohner,

Science Translational Medicine · 2019 · 68 citations · 46 references

DOI

Concepts

Abstract

of the BMP-2/absorbable collagen sponge (ACS) concentration approved for clinical use. Initial toxicology studies were negative. These results support evaluations of BV-265/CM as an alternative to BMP-2/ACS in clinical trials for orthopedic conditions requiring augmented healing.

References

46

Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions

Gary E. Friedlaender, Clayton R. Perry, J. Dean Cole et al. · Journal of Bone and Joint Surgery · 2001 · 961 citations · Full text

, , +17

The Biology of Bone Grafting

Safdar N. Khan, Frank P. Cammisa, Harvinder S. Sandhu et al. · Journal of the American Academy of Orthopaedic Surgeons · 2005 · 847 citations

, , +17

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing

Kunikazu Tsuji, Amitabha Bandyopadhyay, Brian D. Harfe et al. · Nature Genetics · 2006 · 817 citations

, , +15

Human Bone Morphogenetic Protein 2 Contains a Heparin‐Binding Site which Modifies Its Biological Activity

Rainer Ruppert, Elke Hoffmann, Walter Sebald · European Journal of Biochemistry · 1996 · 553 citations

, , +13

<i>ACVR1</i> <sup> <i>R206H</i> </sup> receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

Sarah Hatsell, Vincent Idone, Dana M. Alessi Wolken et al. · Science Translational Medicine · 2015 · 445 citations · Full text

, , +17