Therapeutic effect of lycopene-rich tomato juice on cardiac disorder in rats fed on fried food in oxidized frying oil

Abstract

Therapeutic effect of lycopene-rich tomato juice against evoked cardiac disorders in rats fed on fried potato in oxidized frying cotton seed oil (20% w/w ) for 4-weeks was studied using lycopene at a daily dose of 1 mg/Kg body weight. Total lipids, total cholesterol, triglycerides, phospholipids, low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) were estimated in different animal groups. Lactic dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as well as serum calcium, potassium and magnesium were determined The obtained results revealed that, feeding on fried potato in deep oxidized frying oil induced a notable increase in lipid profils and LDL-c associated with a marked elevation in specific heart enzymes, LDL, CK, ALT and AST activities. These biochemical alterations ameliorated when lycopene was administered to rats fed fried potato in oxidized frying oil.