A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer

Joseph A. Sparano, Robert J. Gray, Della Makower et al. · New England Journal of Medicine · 2018 · 2.4K citations · Full text

Medicine, Endocrinology, Oncology +17

Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

Csaba Szabó, Ciro Coletta, Celia Chao et al. · Proceedings of the National Academy of Sciences · 2013 · 753 citations · Full text

Medicine, Oncology, Pharmacology +15

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

Norihiro Shibuya, Shin Koike, M. Tanaka et al. · Nature Communications · 2013 · 554 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer

Toshio Shimizu, Anthony W. Tolcher, Kyriakos P. Papadopoulos et al. · Clinical Cancer Research · 2012 · 432 citations

Medicine, Oncology, Pharmacology +17

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

Ruth Scherz‐Shouval, Sandro Santagata, Marc L. Mendillo et al. · Cell · 2014 · 421 citations · Full text

Medicine, Cancer Biology, Molecular Biology +12