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Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

Medicinal ChemistryPharmaceutical ScienceAnti-inflammatoryBiochemistryMedicineNatural SciencesRational Drug DesignStructure-based DesignCathepsin CNon-peptide LigandChemical BiologyPharmacologyRheumatoid ArthritisDrug Discovery