Concepedia

HCP5 is a SMAD3-responsive long non-coding RNA that promotes lung adenocarcinoma metastasis via miR-203/SNAI axis

Ranran Wang, Li Fang, Xiaolu Ge, Lingna Chen, Ming Zhou, Yanhong Zhou, Wei Xiong, Yerong Hu, Xianming Tang, Guiyuan Li,

Theranostics · 2019 · 110 citations · 42 references

DOIFull text

Open access

Concepts

Abstract

: Our work demonstrates that the lncRNA HCP5 is transcriptionally regulated by SMAD3 and acts as a new regulator in the TGFβ/SMAD signaling pathway. Therefore, HCP5 can serve as a potential therapeutic target in LUAD.

References

42

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Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 87.7K citations · Full text

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FIMO: scanning for occurrences of a given motif

Charles E. Grant, Timothy L. Bailey, William Stafford Noble · Bioinformatics · 2011 · 4.9K citations · Full text

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Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

Nicolas Coudray, Paolo Ocampo, Theodore Sakellaropoulos et al. · Nature Medicine · 2018 · 2.9K citations · Full text

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Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Silvia Novello, Fabrice Barlési, Raffaele Califano et al. · Annals of Oncology · 2016 · 2.6K citations · Full text

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