Concepedia

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies

Lexian Tong, Pinrao Song, Kailong Jiang, Lei Xu, Tingting Jin, Peipei Wang, Xiaobei Hu, Fang Sui, Anhui Gao, Yubo Zhou,

European Journal of Medicinal Chemistry · 2019 · 25 citations · 22 references

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References

22

Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Hui Zhao, Helen Piwnica‐Worms · Molecular and Cellular Biology · 2001 · 1.1K citations · Full text

UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

Qizhi Wang, Songqing Fan, Alan Eastman et al. · JNCI Journal of the National Cancer Institute · 1996 · 447 citations · Full text

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

Matilde Murga, Stefano Campaner, Andrés J. López‐Contreras et al. · Nature Structural & Molecular Biology · 2011 · 382 citations · Full text

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LigScore: a novel scoring function for predicting binding affinities

André Krammer, Paul D. Kirchhoff, Xiaohui Jiang et al. · Journal of Molecular Graphics and Modelling · 2004 · 379 citations

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