Lexian Tong

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies

Lexian Tong, Pinrao Song, Kailong Jiang et al. · European Journal of Medicinal Chemistry · 2019 · 25 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +7

Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT

Lexian Tong, Peipei Wang, Xuemei Li et al. · Journal of Medicinal Chemistry · 2022 · 20 citations · Full text

Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia

Kailong Jiang, Xuemei Li, Chang Wang et al. · Leukemia · 2022 · 17 citations

Hematological Malignancy, Tumor Biology, Chk1/flt3 Enhances Cytotoxicity +11

Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling

Jinxin Che, Dan Li, Wenxiang Hong et al. · European Journal of Medicinal Chemistry · 2022 · 14 citations

Inflammation, Cytokine, Medicine +12

Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies

Kailong Jiang, Lexian Tong, Tao Wang et al. · Acta Pharmacologica Sinica · 2021 · 10 citations · Full text

Hematological Malignancy, Tumor Biology, Oncogenic Agent +10