Concepedia

Targeting β-catenin overcomes MEK inhibition resistance in colon cancer with KRAS and PIK3CA mutations

Jai-Hee Moon, Seungwoo Hong, Jeong Eun Kim, Jae-Sik Shin, Jin‐Sun Kim, Soo-A Jung, Seung Hee Ha, Seul Lee, Joseph Kim, Dae Hee Lee,

British Journal of Cancer · 2019 · 45 citations · 12 references

DOIFull text

Open access

Abstract

We propose that inhibition of the WNT pathway, particularly β-catenin, may bypass resistance to MEK inhibition in human PIK3CA mt colon cancer. Therefore, we suggest that β-catenin is a potential predictive marker of MEK inhibitor resistance.

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