Factors affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxp system

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

S. E. Luria, M. Delbrück · Genetics · 1943 · 3.9K citations

Life Sciences, Genetics, Microbiology +17

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

Martin Hooper, Kate Hardy, Alan H. Handyside et al. · Nature · 1987 · 1.2K citations

Life Sciences, Developmental Biology, Genetics +16

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

Jorge A. Piedrahita, S H Zhang, John R. Hagaman et al. · Proceedings of the National Academy of Sciences · 1992 · 926 citations

Life Sciences, Genetics, Molecular Genetics +10

Gene transfer with subsequent removal of the selection gene from the host genome.

Emily C. Dale, David W. Ow · Proceedings of the National Academy of Sciences · 1991 · 425 citations

Life Sciences, Biotechnology, Genetics +17

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

Paul Hasty, Ramiro Ramírez‐Solis, Robb Krumlauf et al. · Nature · 1991 · 334 citations

Life Sciences, Developmental Biology, Genetics +16