Concepedia

HMGB1-Induced p62 Overexpression Promotes Snail-Mediated Epithelial-Mesenchymal Transition in Glioblastoma Cells via the Degradation of GSK-3β

Hong Li, Junjie Li, Guozhong Zhang, Qian Da, Lei Chen, Shishi Yu, Qiang Zhou, Zhijian Weng, Zong Xin, Linyong Shi,

Theranostics · 2019 · 85 citations · 47 references

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Abstract

This study suggests that p62 is an effector for HMGB1-induced EMT, and may represent a novel therapeutic target in GBM.

References

47

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

Heidi Phillips, Samir Kharbanda, Ruihuan Chen et al. · Cancer Cell · 2006 · 3.2K citations · Full text

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A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

Mark R. Gilbert, James J. Dignam, Terri S. Armstrong et al. · New England Journal of Medicine · 2014 · 2.8K citations · Full text

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The transcriptional network for mesenchymal transformation of brain tumours

Maria Stella Carro, Wei Keat Lim, Mariano J. Alvarez et al. · Nature · 2009 · 1.3K citations

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Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation

M. Lamar Seibenhener, Jeganathan Ramesh Babu, Thangiah Geetha et al. · Molecular and Cellular Biology · 2004 · 704 citations · Full text

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A Wnt–Axin2–GSK3β cascade regulates Snail1 activity in breast cancer cells

Jong In Yook, Xiaoyan Li, Ichiro Ota et al. · Nature Cell Biology · 2006 · 612 citations · Full text

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