Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca ²⁺ -ATPase in Heart Failure

Abstract

These results indicate that acetylation/deacetylation at K492, which is regulated by SIRT1 and p300, is critical for the regulation of SERCA2a activity in hearts. Pharmacological activation of SIRT1 can restore SERCA2a activity through deacetylation at K492. These findings might provide a novel strategy for the treatment of heart failure.