Phosphorylation of <scp>GATA</scp>4 serine 105 but not serine 261 is required for testosterone production in the male mouse

Abstract

Our analysis showed that blocking GATA4 S105 phosphorylation is associated with decreased androgen production in males. In contrast, S261 phosphorylation by itself is dispensable for GATA4 function. These results confirm that endogenous GATA4 action is essential for normal steroid production in males and that this activity requires phosphorylation on at least one serine residue.