Cell Reports · 2019 · 43 citations · 70 references
Life SciencesNeurobiologyNeuroscienceMolecular NeurobiologyMolecular NeuroscienceNeurobiophysicsNeurotransmissionSnare-mediated FusionSynaptic SignalingSynaptic TransmissionSynaptic Vesicle ReleaseVesicle FusionCa2+ SignalingChargesElectrostatic RepulsionEvoked ReleaseSnare ProteinsSnare-mediated Vesicle FusionSynaptic Vesicle DynamicsVesicle Fusion Machinery
, while also modulating the fusion barrier at rest. Thus, the energy barrier for synaptic vesicle fusion has a large electrostatic component, allowing synaptotagmin-1 to act as an electrostatic switch and modulator to trigger vesicle fusion.
70
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Luigi Naldini, Ulrike Blömer, Philippe Gallay et al. · Science · 1996 · 4.9K citations
SNAREpins: Minimal Machinery for Membrane Fusion
Thomas Weber, Boris V. Zemelman, James A. McNew et al. · Cell · 1998 · 2.5K citations · Full text
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
R. Bryan Sutton, Dirk Fasshauer, Reinhard Jahn et al. · Nature · 1998 · 2.4K citations
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
Martin Geppert, Yukiko Goda, Robert E. Hammer et al. · Cell · 1994 · 1.5K citations · Full text