Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Martin Citron, Tilman Oltersdorf, Christian Haass et al. · Nature · 1992 · 1.7K citations

Neurodegenerative Diseases, Alzheimer's Disease, β-Amyloid Precursor Protein +10

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ ₄₂ in humans

Anne M. Fagan, Mark A. Mintun, Robert H. Mach et al. · Annals of Neurology · 2005 · 1.2K citations

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski et al. · Proceedings of the National Academy of Sciences · 2003 · 750 citations · Full text

Alzheimer's disease drug development pipeline: 2018

Jeffrey L. Cummings, Garam Lee, Aaron Ritter et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 2018 · 705 citations · Full text

Depressive symptoms and risk of dementia

Jane S. Saczynski, Alexa Beiser, Sudha Seshadri et al. · Neurology · 2010 · 473 citations · Full text