Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway

The effect of particle design on cellular internalization pathways

Stephanie E. A. Gratton, Patricia A. Ropp, Patrick D. Pohlhaus et al. · Proceedings of the National Academy of Sciences · 2008 · 2.9K citations · Full text

Nanoparticles, Tissue Engineering, Colloidal Material +21

Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis

Joanna Rejman, Volker Oberle, Inge S. Zuhorn et al. · Biochemical Journal · 2004 · 2.8K citations · Full text

Molecular Biology, Extracellular Microvesicles, Cytoskeleton +22

Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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Inflammation, Host Response, Allergy +10

Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

Veit Hornung, Margit Guenthner‐Biller, Carole Bourquin et al. · Nature Medicine · 2005 · 1.2K citations · Full text

Innate Immune System, Immunology, Immune Regulation +16