Concepedia

Publication | Closed Access

Antifibrotic Agent Pirfenidone Suppresses Proliferation of Human Pancreatic Cancer Cells by Inducing G0/G1 Cell Cycle Arrest

DOI

31

Citations

0

References

2019

Year

Eri Usugi, Kenichiro Ishii, Yoshifumi Hirokawa, Kazuki Kanayama, Chise Matsuda, Katsunori Uchida, Taizo Shiraishi, Masatoshi Watanabe
Pharmacology

Abstract

These results demonstrated that the antifibrotic agent PFD might have antiproliferative effects on PCCs by inducing G0/G1 cell cycle arrest. This suggests that PFD may target not only fibroblasts but also PCCs in the tumor microenvironment of pancreatic cancer.