<i>Pseudomonas aeruginosa</i>stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury

Abstract

Our studies define a critical role for nuclear SPHK2/S1P signalling in epigenetic regulation of bacterial-mediated inflammatory lung injury. Targeting SPHK2 may represent a potential strategy to reduce lung inflammatory pulmonary disorders such as pneumonia and CF.