Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

Stuart M. Pitson, Pu Xia, Tamara Leclercq, +5

The Journal of Experimental Medicine

ApoptosisCell DeathCellular PhysiologyHuman SkSignaling Pathway +15

Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation

Stuart M. Pitson, Paul A.B. Moretti, Julia R. Zebol, +5

Journal of Biological Chemistry

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

Kate E. Jarman, Paul A.B. Moretti, Julia R. Zebol, +1

Journal of Biological Chemistry

The Nucleotide-binding Site of Human Sphingosine Kinase 1

Stuart M. Pitson, Paul A.B. Moretti, Julia R. Zebol, +8

Journal of Biological Chemistry

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis

Kate A. Parham, Julia R. Zebol, Katie L. Tooley, +8

The FASEB Journal

Pparγ FunctionsCellular PhysiologyTranscriptional RegulationAngiogenesisSignaling Pathway +14

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties

Melissa R. Pitman, Jason A. Powell, Carl Coolen, +9

Oncotarget

An oncogenic role for sphingosine kinase 2

Heidi A. Neubauer, Duyen Pham, Julia R. Zebol, +11

Oncotarget

Plasma Membrane LocalizationApoptosisCell DeathPathologySphingosine Kinase 2 +18

Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress

Craig T. Wallington‐Beddoe, Melissa K. Bennett, Kate Vandyke, +7

Oncotarget

Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3′ untranslated region of dengue virus type-2 RNA

Jillian M. Carr, T. Kua, Jennifer N. Clarke, +4

Journal of General Virology

Lipid KinaseViral ReplicationMolecular VirologySphingosine Kinase 1Untranslated Region +12

Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma

Heidi A. Neubauer, Melinda N. Tea, Julia R. Zebol, +12

Oncogene