Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine

o-phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids

Barry Jones, James P. Gilligan · Journal of Chromatography A · 1983 · 529 citations

Pharmacy, Biochemistry, Chromatographic Analysis +13

Overexpression and Large-Scale Production of Recombinantl-Methionine-α-deamino-γ-mercaptomethane-lyase for Novel Anticancer Therapy

Yuying Tan, Mingxu Xu, Xuezhong Tan et al. · Protein Expression and Purification · 1997 · 191 citations

Medicine, Biomolecular Engineering, Oncology +7

Reversible growth arrest in simian virus 40-transformed human fibroblasts.

Robert M. Hoffman, Steven J. Jacobsen · Proceedings of the National Academy of Sciences · 1980 · 169 citations · Full text

Life Sciences, Cell Biology, Microbiology +17

Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo.

H Guo, Valeryi K. Lishko, Hector Herrera et al. · PubMed · 1993 · 168 citations

Medicine, Cancer Biology, Oncology +10

Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice.

Xiao Sun, Min Xu, Xiaojun Tan et al. · PubMed · 1999 · 125 citations

Medicine, Oncology, Pharmacology +16