Concepedia

Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN)

Rubina Tuladhar, Nageswari Yarravarapu, Yuyong Ma, Chengwei Zhang, Jeremiah Herbert, James Kim, Chuo Chen, Lawrence Lum

Journal of Biological Chemistry · 2019 · 20 citations · 34 references

DOIFull text

Open access

Concepts

Abstract

fats and to PORCN inhibitors in clinical development.

References

34

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Baozhi Chen, Michael Dodge, Wei‐Jen Tang et al. · Nature Chemical Biology · 2009 · 1.4K citations · Full text

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Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

Jing Yang, Michael S. Brown, Guosheng Liang et al. · Cell · 2008 · 1.2K citations · Full text

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The EMBL-EBI bioinformatics web and programmatic tools framework

Weizhong Li, Andrew Cowley, Mahmut Uludağ et al. · Nucleic Acids Research · 2015 · 1.1K citations · Full text

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Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

Baolin Wang, John F. Fallon, Philip A. Beachy · Cell · 2000 · 1K citations · Full text

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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Jun Liu, Shifeng Pan, Mindy H. Hsieh et al. · Proceedings of the National Academy of Sciences · 2013 · 835 citations · Full text

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