Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation

Sarah Mundt, Dunja Mrdjen, Sebastian G. Utz, Melanie Greter, Bettina Schreiner, Burkhard Becher

Science Immunology · 2019 · 241 citations · 44 references

Concepts

Abstract

cells in vivo. We found a population of conventional dendritic cells, but not border-associated macrophages or microglia, to be essential for licensing T cells to initiate neuroinflammation.

References

44