Concepedia

<p>Overexpression of COL5A1 promotes tumor progression and metastasis and correlates with poor survival of patients with clear cell renal cell carcinoma</p>

Gang Feng, Huimin Ma, Houbao Huang, Yawei Li, Peng Zhang, Jianjun Huang, Long Cheng, Guorong Li

Cancer Management and Research · 2019 · 45 citations · 23 references

DOIFull text

Open access

Abstract

COL5A1 knockdown significantly inhibited cell proliferation, induced cell apoptosis, inhibited cell migration and invasion in vitro, and inhibited tumor growth in vivo. Therefore, COL5A1 may be a novel prognostic biomarker and a promising therapeutic target for ccRCC.

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