Precise tuning of gene expression levels in mammalian cells

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Manfred Gossen, Heidelberg Bujard · Proceedings of the National Academy of Sciences · 1992 · 4.9K citations

Viral Replication, Molecular Regulation, Immunology +20

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

Andrew Grimson, Kyle Kai‐How Farh, Wendy K. Johnston et al. · Molecular Cell · 2007 · 3.8K citations · Full text

Genetics, Microrna Targeting Specificity, Microrna Detection +5

A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

Pablo Landgraf, Mirabela Rusu, Robert P. Sheridan et al. · Cell · 2007 · 3.6K citations · Full text

Systems Biology, Functional Genomics, Engineering +9

T cell receptor antagonist peptides induce positive selection

Kristin A. Hogquist, Stephen C. Jameson, William R. Heath et al. · Cell · 1994 · 2.8K citations

T-regulatory Cell, Immunology, Positive Selection +7

Automated design of synthetic ribosome binding sites to control protein expression

Howard M. Salis, Ethan A. Mirsky, Christopher A. Voigt · Nature Biotechnology · 2009 · 1.9K citations · Full text

Engineering, Protein Expression, Protein Folding +14