Concepedia

Melanocortin type 4 receptor–mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats

Yuan Zhang, Dongsheng Jiang, Hua Li, Yufang Sun, Xinghong Jiang, Shan Shan Gong, Zhiyuan Qian, Jin Tao

Journal of Biological Chemistry · 2019 · 38 citations · 48 references

DOIFull text

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Concepts

Abstract

-protein and downstream class I PI3K-dependent p38α signaling, thereby increasing TG neuronal excitability and mechanical pain sensitivity in rats.

References

48

Efficient Analysis of Experimental Observations

W. J. Dixon · The Annual Review of Pharmacology and Toxicology · 1980 · 2.2K citations

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Downregulation of Transient K<sup>+</sup>Channels in Dendrites of Hippocampal CA1 Pyramidal Neurons by Activation of PKA and PKC

Dax A. Hoffman, Daniel Johnston · Journal of Neuroscience · 1998 · 378 citations · Full text

, , +17

Distinct potassium channels on pain-sensing neurons

Matthew N. Rasband, Eunice W. Park, Todd W. Vanderah et al. · Proceedings of the National Academy of Sciences · 2001 · 358 citations · Full text

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The Kv4.2 Potassium Channel Subunit Is Required for Pain Plasticity

Huijuan Hu, Yarimar Carrasquillo, Farzana Karim et al. · Neuron · 2006 · 252 citations · Full text

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ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit

Laura A. Schrader, Shari G. Birnbaum, Brian M. Nadin et al. · American Journal of Physiology-Cell Physiology · 2005 · 179 citations

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