Concepedia

<i>Porphyromonas gingivalis</i> in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Stephen S. Dominy, Casey Lynch, Florian Ermini, Małgorzata Benedyk, Agata Marczyk, Andrei W. Konradi, Mai Nguyen, Ursula Haditsch, Debasish Raha, Christina Griffin,

Science Advances · 2019 · 1.8K citations · 86 references

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Abstract

Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.

References

86

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless · Angewandte Chemie International Edition · 2001 · 13K citations

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science · 1993 · 9.5K citations

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Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless · Angewandte Chemie International Edition · 2001 · 9.3K citations · Full text

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The antibiotic resistance crisis: part 1: causes and threats.

C Lee Ventola · PubMed · 2015 · 4.7K citations

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The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia, James E. Kirby, Kevin J. Washicosky et al. · PLoS ONE · 2010 · 1K citations · Full text

, , +17