Concepedia

Identification of biologic agents to neutralize the bicomponent leukocidins of <i>Staphylococcus aureus</i>

Rita Chan, Peter T. Buckley, Aidan O’Malley, William E. Sause, Francis Alonzo, Ashira Lubkin, Kristina M. Boguslawski, Angela Payne, Jeffrey Fernandez, William R. Strohl,

Science Translational Medicine · 2019 · 27 citations · 41 references

DOI

Concepts

Abstract

Small protein biologics called centyrins can be engineered to combat the toxicity caused by systemic Staphylococcus aureus infection.

References

41

Genome and virulence determinants of high virulence community-acquired MRSA

Tadashi Baba, Fumihiko Takeuchi, Makoto Kuroda et al. · The Lancet · 2002 · 1.4K citations

, , +14

Complete genomes of two clinical <i>Staphylococcus aureus</i> strains: Evidence for the rapid evolution of virulence and drug resistance

Matthew T. G. Holden, Edward J. Feil, Jodi A. Lindsay et al. · Proceedings of the National Academy of Sciences · 2004 · 904 citations · Full text

, , +17

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar, Thomas H. Pillow, Min Xu et al. · Nature · 2015 · 833 citations

, , +10

Staphylococcal Coagulase: Mode of Action and Antigenicity

E. S. Duthie, L. Lorenz · Microbiology · 1952 · 622 citations

, , +12

Genome Sequence of <i>Staphylococcus aureus</i> Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands

Tadashi Baba, Taeok Bae, Olaf Schneewind et al. · Journal of Bacteriology · 2007 · 568 citations · Full text

, , +17