Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

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Medicine, Endocrinology, Pharmacology +17

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Yasuaki Itoh, Yuji Kawamata, Masataka Harada et al. · Nature · 2003 · 1.5K citations

Life Sciences, Cell Biology, Endocrinology +16

The use of animal models in diabetes research

Aileen King · British Journal of Pharmacology · 2012 · 1.3K citations · Full text

Medicine, Endocrinology, Pharmacology +17

The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

Celia P. Briscoe, Mohammad Tadayyon, John L. Andrews et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity

Marcos L. Sznaidman, Curt D. Haffner, Patrick Maloney et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 311 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11