Impact of Particle-Size Reduction on the Solubility and Antidiabetic Activity of Extracts of Leaves of <i>Vinca rosea</i>

Abstract

OBJECTIVES: ) by particle-size reduction using milling and to evaluate its antidiabetic activity. MATERIALS AND METHODS: antidiabetic activity. RESULTS: The average particle size of MME was 0.753±0.227 μm, which was less than half of that of the ME (2.007±0.965 μm). The solubility of MME was greater than that of the ME. MME exhibited 65.63%, 18.0%, and 96.87% higher antidiabetic activity in the glucose uptake by the yeast cells method, hemoglobin glycosylation assay, and the alpha amylase inhibition assay, respectively (p<0.05). CONCLUSION: .