Survival and functionality of xeno‐free human embryonic stem cell–derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits

Abstract

Xenografted xeno-free hESC-RPE monolayers can survive and retain some functionality for 4 weeks following short-term immunosuppression. The preliminary findings of this study suggest that further investigations to improve transplantation success of hESC-RPE xenografts in rabbits should be addressed especially toward the roles of hESC-RPE maturation stage and extended intravitreal immunosuppression.